Protein hydrolysate for satiety

DNF-10® is a protein hydrolysate from Saccharomyces cerevisiae. Active on the mediators of satiety, DNF-10® helps to lower calorie intake and reduce body fat mass. Benefits have been clinically demonstrated after the first weeks of use. 500mg/day. 


The patented ingredient DNF-10® is an active fraction obtained after protein hydrolysis of Saccharomyces cerevisiae, a yeast species used for thousands of years in baking, fermented food and beverage manufacturing processes. The manufacturing of DNF-10® involves enzymatic proteolysis and a selection of peptides with a molecular weight  <10kDa after an ultrafiltration step. The material is then spray-dried to obtain a dried powder. 

Recommended daily dosage: 500 mg

Mechanism of action

DNF-10®: decreasing food intake

A significant action on the modulators of short-term food intake at the hypothalamic level (NPY) and at the digestive level with a reduction in the hunger hormone ghrelin have been demonstrated.

Over the longer-term, DNF-10® also regulates our cellular secretion of leptin, the satiety hormone.

Clinical studies

DNF-10® benefits have been studied in several clinical studies on a total of 135 subjects involving different delivery systems.

Key features

  • Selected peptidic fraction from Saccharomyces cerevisiae
  • Clinically proven benefits on a total of 135 subjects
  • Reduction of caloric intake significant after the first weeks (down to -600kcal/day after 8 weeks)
  • Significant weight loss after the first month
  • Weight loss is from fat mass reduction
  • Abdominal fat and waist circumference significantly decrease
  • Water-soluble and heat-resistant; suitable for supplements and functional foods
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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This website is intended to provide information about Fytexia’s ingredients, used in various dietary supplement products around the world. It is intended to provide information to food supplement professionals and is not designed for the general public. As Fytexia’s ingredients are being marketed in a large number of countries, it is the responsibility of each of our customers to ensure that the use of the ingredient and any claim made in the labeling or advertising of the ingredient comply with the applicable rules and regulations.