2019/10/08
Sinetrol, the citrus polyphenol-based ingredient targeting body composition improvement, has been extensively studied during the last years. A new published South Korean investigation on the mechanism of action reinforces the understanding on the lipolysis amplification resulting from the regular consumption of Sinetrol (Journal of the Korean Society of Food Science and Nutrition; 45(4), 484-491(2016)): Sinetrol acts by facilitating lipolysis through a 2-step action on lipase activity and expression of the uncoupling protein (UCP) in mitochondria.
The effect of Sinetrol on human metabolism has been demonstrated by clinical studies on over 250 subjects on overweight and obese populations. Based on this scientific dossier Sinetrol is now granted by the MFDS (formerly KFDA) as an approved weight management ingredient:
◼ Rebalance of body composition: reduction of the excess of fat mass & increase of lean mass
◼ Reduction of abdominal fat, waist line, hip line
◼ Increased body tone and lean-to-fat mass ratio
◼ Increased resting energy expenditure (+181kcal/day) through beigeing benefits
Download the science pack to access the full publications
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2019/09/30
Sinetrol, a proprietary nutraceutical ingredient targeting improvement of body composition, developed by Fytexia (France) has been granted with an individual approval associated to an authorized health claim by the South Korean Ministry of Food & Drug Safety (MFDS), formerly known as KFDA.
Fytexia associated with Korean pharmaceutical leader RP Bio and local agency from Japanese distributor Asahi Godo to submit to the MFDS a dossier supporting the application of Sinetrol on improvement of body composition. Independent mechanistic and clinical study on Korean population have been financed and piloted by RP Bio in Seoul to complete the scientific dossier developed by Fytexia.
“This is a positive conclusion to several years of clinical research and it proves the efficacy of Sinetrol on management of body composition” says Matthieu Arguillere, CEO of Fytexia. “We are confident that this positive scientific opinion will allow wider applications of our extract in supplements and functional food as we believe weight management is and will remain a major concern worldwide”.
Read the full press release bellow.
2019/02/19
Globally, the daily intake remains well below the level of 5 servings of fruit and veggies recommended by the World Health Organization. Although the antioxidant capacity of food is derived from the accumulative and synergetic antioxidant power of vitamins, polyphenols, carotenoids and other minor constituents, polyphenols are the main antioxidants present in fruit and vegetables. Focusing on the primary definition of "dietary supplement", Fytexia developed Oxxynea "5-a-day" to complete the serving of antioxidants people may under-consume each day.
Formulated from extracts of grape, olive, pomegranate, green tea, grapefruit, bilberry and orange, Oxxynea “5-a-day” is a newly developed grade of Oxxynea supplying the polyphenol content and antioxidant capacity of 5 servings of fruit & vegetables in 450mg.
> Custom sizing to target your nutritional objective
Oxxynea 5-a-day is recommended at a dosage multiple of 90mg, each portion equaling 1 serving of fruit and vegetables:
A non-GMO, gluten-free, water-soluble powder, Oxxynea is suitable in any kind of delivery system: capsules, tablets, functional food, drinks, gummies, etc.
> Download the science pack to understand how the equivalence with fruit & vegetable antioxidant has been scientifically set up and discover the clinically proven benefits.
2019/01/24
We live in an obesogenic environment at the origin of the epidemic weight gain we observe; escape from this is far from straightforward. Energy balance requires an ability of the brain to detect the status of energy stores and match energy intake with expenditure, implicating numerous mediators of appetite and satiety. This basic function results in a physiological regulation loop that can be exacerbated by stimuli of everyday life (sensorial, emotional etc.).
Helping the body to reduce hunger can be achieved by a new solution offered by Fytexia, based on the mediation of appetite hormones: leptin and ghrelin. DNF-10 supports the reduction of food intake with a very convenient daily dosage, easy to formulate.
DNF-10 is a new ingredient promoting weight management trought the reduction of appetite as proven with 4 published clinical studies on more than 130 subjects.
Obtained from a screening of small molecular weight peptides (<10kDa) after proteolysis of Saccharomyces cerevisiae, DNF-10 addresses weight management through a regulation of the mediators of satiety in the hypothalamus and digestive tract: download the white paper bellow to acces the mechanism of action.
>> Efficient from the first week on food intake
>> Significant body weight loss after the first month
Download the clinical data in the science pack bellow.
2018/12/13
Fiit-ns works on the duality between feeling energy throughout the day, leading to a more active day-to-day life, and improvement in metabolic status for a long term action that promotes healthy aging.
How will Fiit-ns provide healthy aging to consumers?
This holistic approach aims to improve Quality of Life, an outcome proven in 2 clinical studies:
✓ 1 study published in the International Journal of Food Sciences and Nutrition
✓ 1 clinical study publication pending on a total of 89 subjects
Download the science pack bellow.
Download the dedicated brochures on www.fiitns.com
2018/11/06
A new grade of Oxxynea® has been developed to equal the polyphenol content and antioxidant capacity of 5 servings of fruit & vegetables in 450mg.
Fytexia reinforces knowledge of the benefits of polyphenols with a new study conducted in a double-blind, randomized, placebo-controlled cross-over protocol on subjects enduring induced oxidative stress. Bioavailability of Oxxynea® was evaluated by analyzing metabolites of the polyphenols. Results confirmed that the wide variety of polyphenols in Oxxynea® plays a biological role in the whole-day protection of the organism.
Oxxynea® 5-a-day is recommended at a dosage multiple of 90mg, each portion equaling 1 serving of fruit and vegetables, suitable in any kind of delivery system.
Download the clinical report bellow.
2018/10/30
Fytexia extends its weight management range of clinically proven solutions with DNF-10, a new ingredient supported by 4 published clinical studies.
Obtained from a screening of small molecular weight peptides (<10 kDa) after proteolysis of Saccharomyces cerevisiae, DNF-10 addresses weight management through a regulation of the mediators of satiety in the hypothalamus and digestive tract.
Clinical studies show that a daily intake of 500 mg of DNF-10 significantly decreases the caloric intake of supplemented subjects by 200kcal/day after the first week, to reach a total reduction in caloric ingestion of 600 kcal/day after 2 months. This lower intake of food results in significant body weight loss after 4 weeks. Measured with computed tomography, the weight loss is from a reduction in fat mass.
Water-soluble and heat-resistant, DNF-10 is recommended at a dosage of from 500 mg/day for the formulation of dietary supplements and functional foods.
The science pack downloadable below offers an overview of the main outcomes on weight loss, with access to the set of published studies.
2018/05/09
Consumers are looking for effective solutions & durable benefits over time.
Fytexia advances beyond the last gold standard clinical trial with a 4-week follow-up study on the potential prevention of the rebound weight gain effect with Sinetrol. After the supplementation, results showed that not only did subjects not regain the weight they lost, but they continued to reach a healthier body composition by a further loss of fat mass.
Sinetrol is a citrus based ingredient clinically proven to burn fat, as demonstrated in 3 trials, on more than 190 subjects.
✓ Fat mass significantly decreased while lean mass significantly increased: both effects persist and amplify after the supplementation period
✓ Enhanced weight loss results 4 weeks after the end of the supplementation: long-lasting benefits preventing the rebound effect
Download the science pack to access the results
Download the dedicated brochures on www.sinetrol.com
2018/05/02
Sinetrol Active Living is a new weight management ingredient for active people, helping individuals enhance the benefits of the physical activity they perform.
Behaviors toward dieting evolve. Consumers have shifted to a holistic health focus where weight management is seen as part of an overall healthy lifestyle, and sports is included in any fat loss strategy.
Based on the efficacy of citrus polyphenols for amplifying lipolysis, Sinetrol Active Living combines extracts of orange & grapefruit with L-carnitine.
Studies show Sinetrol Active Living:
Download the science pack:
2018/03/21
Fiit-ns® is a combination of bioactive polyphenols from fruit & vegetables and vitamin B3 developed to counter a lack of vitality throughout the day.
Consumers are looking for benefits they can feel and experience: subjects taking Fiit-ns® reported an overall increase in well-being and feelings of vitality as demonstrated in 2 clinical studies on 89 subjects.
Fiit-ns® and the vitamin B3 it contains contribute to the reduction of tiredness and fatigue.
(EFSA Claims ID-2010;8(10):1757)
Download the Science Pack - Vitality Issue to access the clinical studies:
2018/01/25
WHO promotes fruit and vegetables consumption and recommends a minimum daily consumption of 400g as 5 portions.
In the facts, the consumption is much lower; it is estimated that 50 to 75% of the global population don’t eat the 5 servings of fruit and vegetables. In addition, unhealthy eating habits may impair the antiradical defense potential, leading to higher free radicals occurrence in the body.
Oxxynea® FP is an innovative mix of 22 fruit & vegetables concentrate providing a spectrum of bioactive polyphenols: a daily dose of 800mg equates to the antioxidant capacity of 5 servings of F&V.
Oxxynea® is scientifically proven to provide both a quantity of polyphenols and an antioxidant protection:
Download the article on the button below:
2017/11/27
✓ Natural citrus polyphenols
✓ Unique and patented mechanism of action
✓ Weight loss proven in more than 190 subjects: new clinical results
Sinetrol® is clinically proven to reduce the excess of fat mass. These benefits rely on its unique and patented mechanism of action – the Fat Shredding Technology®: the active compounds of Sinetrol® naturally enhance the release of free fatty acids from fat cells.
With weight-loss benefits demonstrated in two previous clinical studies, Fytexia has deepened the scientific evidences with a third gold-standard clinical study:
A double-blind and randomized study in 77 obese or overweight women and men supplemented with 900 mg/day of Sinetrol® in 2 capsules or a placebo:
✓ Supplementing a normo-caloric diet with Sinetrol® led to the support of a healthy body composition: body fat decreased while lean mass increased.
✓ The Sinetrol®-supplemented group reduced their excess of fat mass by 63% compared to the theoretical fat mass.
> Altogether, Sinetrol® is proven to be a safe solution for reducing excess body weight in more than 190 subjects.
Click on the button below to download the clinical reports
2017/09/20
This white paper demonstrates the added value polyphenols can bring to sports nutrition formulas by providing acute clinically proven benefits for pre- and post-workout. Download it on the buton bellow.
Bioactive polyphenols constitute a wide family of phytochemicals and their benefits for sports are becoming a large subject of research. Expert in the science of polyphenols, Fytexia brings out the vast potential of these natural bioactives for immediate performance with PerLoad® and faster recovery with TensLess®.
PerfLoad®: Heavier performance – polyphenols strength for explosive peak power
Combines extracts of grape, pomegranate and green tea for a clinically-proven effect on total anaerobic work capacity and peak power when taken pre-workout at a 1g dosage, while limiting the deleterious effects of by-products generated by intense anaerobic training.
TensLess®: Faster recovery – polyphenols to restore physical capacity
Designed to help significantly reduce muscle soreness and pain after a training session, using a combination of mangosteen, pomegranate and elderberry which showed efficacy in a double-blind, placebo-controlled, crossover study. To be taken post-workout at 1.5g dosage.
>> Access the 2 Published Clinical Studies in the White Paper:
2017/08/16
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United Kingdom, August 2017 – GHP (Global Health & Pharma) magazine, specialized in Human Health, has announced the winners of the 2017 International Life Sciences Awards: Fytexia received the Awards of Best Natural Provider Western Europe with the ingredient Fiit-ns, a botanical metabolic anti-aging.
DOWNLOAD THE CLINICAL DATA BELOW |
2017/06/22
To target a significant reduction in joint discomfort, Fytexia proposes a premium and innovative solution: an extract of mangosteen rich in alpha- and gamma-mangostins, mangoselect®, clinically proven to support joint health.
Clinical study:
• University of Pavia, Italy
• Mangoselect® (600mg/day) or a positive control
• 24 volunteers with acute (15 athletes) or chronic (9 elderly) soft tissue suffering
• Discomfort measured before and after the 5-day supplementation
Download the published article by clicking on the button below.
2017/05/29
✓ Natural citrus polyphenols
✓ Unique and patented mechanism of action
✓ Helps to burn excess stored fat
Review the 3 clinical studies by downloading the Science Pack on the button below:
2017/05/04
The ingredient Fiit-ns is a proprietary combination of botanical extracts from grapefruit, grape, green tea, guarana, black carrot and vitamin B3. Fiit-ns is clinically proven to rejuvenate metabolic markers of Aging to improve Quality of Life (QOL). Benefits of the first clinicial study were published in the International Journal of Food Sciences and Nutrition.
Fytexia increases the scientific evidence with a new randomized, double-blind and placebo-controlled clinical study in 72 subjects.
Fiit-ns was proven to regulate metabolic parameters to reach healthier lipid & glycemic profiles and decrease oxidative stress & inflammation. Improvement of body composition combined with metabolic benefits contributed to significantly improve the reported Quality of Life, as assessed with the SF-36 questionnaire. This is particularly emphasized by increased vitality, well-being, and general feelings of health in the Fiit-ns group.
Click on the buton below to download the dedicated white paper with the full clinical report
2017/04/24
With weight-loss benefits demonstrated in two previous clinical studies, Fytexia has deepened the scientific evidence for Sinetrol® with a third clinical study.
In a double-blind, randomized study, 77 obese or overweight women and men were supplemented with 900 mg/day of Sinetrol® in 2 capsules or a placebo.
The study demonstrated that the polyphenol-rich ingredient is a safe solution for inducing a significant weight-loss. Moreover, the gold standard technology DXA highlighted that supplementing a normo-caloric diet with Sinetrol® led to the support of a healthy body composition: body fat decreased while lean mass increased.
The supplemented group reduced their excess of fat mass by 63% compared to the theoretical fat mass and all the anthropometric parameters were significantly improved at the end of the study (BMI, waist and hip circumferences, etc.).
> Altogether, Sinetrol® is now proven to be a safe solution for reducing excess of body weight, in more than 190 subjects.
Click on the buton below to download the dedicated white paper
2017/03/22
Riding the wave of its new range of sports nutrition ingredients launched at SupplySide West, Fytexia announces the publication of a clinical study in the International Journal of Food Sciences and Nutrition demonstrating the benefits of HolisFiit.
HolisFiit, is based on the health benefits of green tea and yerba mate, associated to additional botanical inspired from the Mediterranean Health benefits and enhanced with vitamin B3.
The 4-month clinical study on 33 subjects confirms the benefits of a supplementation with 1g/day of HolisFiit:
Click on the buton below to download the publication.
2017/03/06
Four polyphenol-based ingredients have been clinically investigated to fulfill athletes and recreationally actives' requirements all along their sports practice.
During this webinar, Fytexia will demonstrate key benefits through concretes results for performance, endurance and recovery. Then, you will discover a breakthrough solution to address a new and growing demand: zen sports.
SIGN UP for the webinar here
2017/02/28
Sports Nutrition is fully part of the workout strategy for anyone looking to perform at a consistent level and to maintain good physical condition to resume training faster. Experience short-term benefits is a key factor to keep on the supplementation and improve the upcoming workout.
Polyphenol-rich formulas targeting Performance and Recovery clinically proved their capacity to provide immediate results during and right after sports practice.
PerfLoad: Heavier performance – polyphenols strength for explosive peak power
Combines extracts of grape, pomegranate and green tea for a clinically-proven effect on total anaerobic work capacity and peak power when taken pre-workout at a 1g dosage, while limiting the deleterious effects of by-products generated by intense anaerobic training.
Download the dedicated brochures on www.perfload.fr
TensLess: Faster recovery – polyphenols to restore physical capacity
Designed to help significantly reduce muscle soreness and pain after a training session, using a combination of mangosteen, pomegranate and elderberry which showed efficacy in a double-blind, placebo-controlled, crossover study. To be taken post-workout at 1.5g dosage.
Download the dedicated brochures on www.tensless.fr
2017/02/09
Sinetrol's powerful Fat Shredding Technology was proven to efficiently support body weight management in 2 published clinical studies involving 115 subjects. This new white paper reveals how does the patented formula of Sinetrol work at the cellular level.
Sinetrol acts through the exclusive mechanism of Fat Shredding Technology to enhance the release of free fatty acids from adipocytes, leading to a reduction of the fat mass on overweight and obese subjects.
Download the new dedicated White Paper below to understand the potential of this exclusive mechanism of action for your dietary supplement formula.
2017/01/24
From early 2000’s, WHO has promoted fruit and vegetables consumption and recommends a minimum daily consumption of 400 g as 5 portions.
In the facts, the consumption is much lower; it is estimated that 50 to 75% of the population don’t eat the 5 servings of fruit and vegetables. In addition, unhealthy eating habits may impair the antiradical defense potential, leading to higher free radicals occurrence in the body.
Provide your customers with a turnkey solution boosting your formula with a full spectrum of polyphenols: Oxxynea.
Fytexia has selected 22 fruit and vegetables to develop this natural ingredient. Oxxynea provides the same antioxidant protection than the daily recommended dose of 5 servings of fruits and vegetables (ORAC and Folin Ciocalteu analysis).
The proven benefits were published in the Journal of Agricultural and Food Chemistry:
Download the article on the button below.
Download the dedicated brochures on www.oxxynea.com
2016/12/06
Target over 250 million yogi worldwide …
… as estimated by the International Yoga Federation. Growing aspirations to slow down the pace of busy lifestyles and achieve a better body-mind balance are fueling the exploding popularity of zen sports. Fytexia's research highlights botanical extracts able to support focus and optimize each zen sport session.
HolisFiit, is based on the health benefits of 2 kinds of tea, green tea and yerba mate, associated to additional botanical inspired from the Mediterranean Health benefits and enhanced with vitamin B3.
The ingredient has been formulated to help subjects practicing body-mind exercises (yoga, taï-shi, Pilates…) to improve their lifestyle with a holistic approach. A 4-month clinical study on 33 subjects confirms the benefits of a supplementation with 1g per day.
Click on the button below to download the clinical results
2016/10/04
Fytexia kicked-off SupplySide West 2016 with a Grand Opening ceremony built around an entirely new line of branded, clinically proven ingredients for sports performance.
The aim of the Fytexia is to bringing out the vast – and mostly unexploited – potential of natural polyphenols for the optimization of physical activity. Under the leadership of Dr Julien Cases, Head of Innovation and Scientific Affairs, Fytexia investigated specific combinations of bioactives from fruit and vegetables and their demonstrable benefits for the active consumer. Through this research, 3 innovative ingredients for key, existing market categories, as well as a breakthrough solution to address a new and growing demand were developped:
PerfLoad® – a performance-enhancing system based on extracts of grape, pomegranate, and green tea
BurntoRun® – a combination of citrus fruits, L-carnitine, and guarana seeds to boost endurance
TensLess® – a recovery accelerator composed of elderberry, mangosteen and pomegranate fruit extracts
HolisFiit® – a solution to maximize the body-mind benefits of wellness-oriented activities such as yoga or pilates.
SupplySide West 2016 marked the completion of the development work, with a launch supported not only by the Grand Opening ceremony and a large booth presence, but also by an entirely redesigned graphic identity for Fytexia’s marketing materials.
2016/06/14
Unhealthy lifestyle and eating habits may impair the antiradical defense potential, leading to higher free radicals occurrence in the body. The Mediterranean diet is reliant mostly on fruit & vegetables, major sources of antioxidants from phenolic compounds that scavenge these free radical species.
Fytexia developed Oxxynea® from a selection of 22 natural extracts and concentrates, bringing an authentic Mediterranean spectrum of bioactive polyphenols, acting synergistically to offer health benefits traditionally found in the Mediterranean diet.
Science Pack available on the download button.
Download the dedicated brochures on www.oxxynea.com
2016/05/19
Fytexia is delighted to announce the opening of a sales office in Asia-Pacific. Driven by the success of our ingredients across Europe and USA, Fytexia is now present in a 3rd office located in the heart of Kuala Lumpur. Were are pleased to dedicate a sales force to help costumers succeed in their projects accross the Asia-Pacific region. Camille Alnet has been appointed to head this new office.
For further information about the news or about the ingredients please contact him at calnet@fytexia.com.
Asia-Pacific Office - FYTEXIA SAS
c/o CCIFM Business Center - Unit No. 2A-6-2, 6th Floor
Plaza Sentral, Jalan Stesen Sentral 5
50470 Kuala Lumpur, Malaysia
+ 60 3 2035 6849
2016/05/09
SINETROL®
Since Sinetrol® proved to efficiently help with body weight management in 2 published clinical studies involving 115 subjects, the new ex-vivo study on human adipocytes reveal the synergetic benefits of polyphenols from the patented formula of Sinetrol®: enhanced lipolytic activity and antioxidant protection.
FIIT-NS®
Fytexia sets up a second clinical study on 92 subjects over 16 weeks on the natural ingredient Fiit-ns®. The synergy of polyphenols and vitamin B3 targeting Quality of Life improvement. Fiit-ns® improves key metabolic parameters and body composition to reach a higher well-being and vitality. The supplementation impacts positively overall lifestyle by promoting healthy aging.
Click on the button below to download the new data
2016/04/13
Since SINETROL® proved to efficiently decrease abdominal fat mass and significantly reduce waist and hip size in 2 published clinical studies involving 115 subjects, its efficacy for managing body weight has been investigated again.
A new ex-vivo study on human adipocytes reveals a synergetic effect from the right combination of polyphenols. By a unique selection of Mediterranean citrus extracts, the effect of each ingredient is potentiated to enhance lipolytic activity and antioxidant protection.
Download the new published White paper of SINETROL® Xpur to learn more about the opportunities this presents for the development of your weight management products clicking on the button below.
Download the dedicated brochures on www.sinetrol.com
2016/03/14
Fytexia releases the first publication supporting Mangoselect®, a natural synergy of Alpha and Gamma mangostins working as COX-2 inhibitors to help relieve joint discomfort after only 5 days.
The efficacy of Mangoselect® has been evaluated in a double-blind randomized, cross-over protocol. After only 5 days, the Alpha and Gamma mangostins from Mangoselect® helped decrease chronic joint discomfort of the elderly (-50%) and acute joint discomfort of sportsmen (-31%).
Mangoselect® can be formulated in tablets, capsules or soft gels.
Daily dosage : 600mg/day.
Click on the button below to download the Science pack including the publication of the scientific article supporting the benefits of Mangoiselect®.
Download the dedicated brochures on www.mangoselect.com
2016/02/17
Everywhere, the demand for clinically proven, natural and safe food supplements is growing.
Fytexia releases the power of polyphenols in 4 ingredients supported with published science.
Click on the button below to download the set of brochures supporting our ingredients.
2016/01/14
Fytexia and Laboratoire Pyc team up to release a new, ready-to-market delivery system to help supplement makers create value in weight management.
Based on SINETROL® Xpur EZ, the stick-pack formula brings clinically proven fat loss benefits within a natural, enjoyable and easy-to-transport product.
Each stick-pack combines the full active dose of SINETROL® Xpur EZ (1,4g/day) with natural flavors and sweeteners for a balance of efficacy and taste. This new customizable solution is designed to meet requirements of worldwide markets and can immediately be used for successful innovation.
Click on the button below to download the Science Pack with full text clinical studies.
Download the dedicated brochures on www.sinetrol.com
2015/10/06
Following a strong growth of its business in the States in the past few years, Fytexia decided to increase its involvement in the industry by signing-up as an Active Member of the American Herbal Products Association.
The company intends to contribute to ongoing changes that will affect the future of the US herbal industry, where its presence has significantly extended since the set-up of Fytexia Corp. in New York City in 2013. Fytexia’s clinically proven ingredients from fruit & vegetables polyphenols can now be found in several leading supplement brands distributed through multiple distribution channels across the country.
According to Lionel Schmitt, President and CEO of Fytexia, “the AHPA is a key influencer on questions related to science, regulations and communication on botanical products, which makes it the perfect fit for us. In order to secure a healthy growth of our business in the US, it’s critical that consumers keep access to high-quality herbal products, and that they can trust labels and claims on those products. We look forward to contributing to that mission within the Association.”
Fytexia will attend its first AHPA events as a member during Supply Side West in Las Vegas next week.
2015/10/02
France's Sales Leaders network (DCF) awarded Fytexia's outstanding sales dynamic worldwide during its biennial "National week of sales parformance", giving the company the Second Prize.
According to a DCF official, Fytexia won the jury's recognition by reporting impressive sales growth outside of France since 2012, making export the source of 93 % of their revenues.
As part of that progression, the company set up an affiliate in New York City in 2013 with the ambition of making the US its dominant market. The relevance of Fytexia's innovative health ingredients in North America was recognized by Canada's health authority, which recently approved their two flagship products for marketing.
The company is now in the process of opening a new sales office in Kuala Lumpur to reach the full potential of Asian markets such as Malaysia, Korea and Indonesia.
2015/09/08
SINETROL®, proven fat burner solution.
SINETROL® is a non-thermogenic synergy of citrus polyphenols stimulating the release of free fatty acids from the adipocytes. Sinetrol helps to burn the stored fat, with no side effect.
With an ex vivo study and 2 clinical studies on a total of 115 people supporting the mechanism of action and the efficacy of Sinetrol, this natural fat burner is now leading the market of weight management solutions.
Click on the button below to download the 3 articles supporting the fat burning activity of SINETROL®
Download the dedicated brochures on www.sinetrol.com
2015/01/29
Fytexia announces the release of Oxxynea® Dtx, a new grade of its proprietary synergy of polyphenols Oxxynea®.
Oxxynea® Dtx offers the same antioxidant potency as 5 portions of fruit and vegetable with a combination of 5 extracts selected for their targeted action on detoxification of the metabolism.
Click on the round button below to download the dedicated science pack.
Download the dedicated brochures on www.oxxynea.com
2014/10/01
Fytexia® announces the publication of the first clinical study carried out on Fiit-ns®, its proprietary Metabolic Anti-Aging Ingredient.
Fiit-ns® is a combination of extracts from grapefruit, grape, green tea, guarana and black carrot, bringing strong antioxidant properties, enhanced with vitamin B3 to increase the feeling of energy while reducing tiredness. Fiit-ns® helps to rejuvenate body parameters, for a metabolic anti-aging action and thus an improvement of quality of life (QOL).
A double-blind, placebo-controlled clinical study has been conducted on 17 subjects.
After 12 weeks, metabolic markers have been improved, with higher energy, higher well being and significant weight loss (-6,1kg) in the Fiit-ns® group.
DOWNLOAD THE SCIENCE PACK CLICKING ON THE BUTTON BELOW
Download the dedicated brochures on www.fiitns.com
2019/10/08
Sinetrol, the citrus polyphenol-based ingredient targeting body composition improvement, has been extensively studied during the last years. A new published South Korean investigation on the mechanism of action reinforces the understanding on the lipolysis amplification resulting from the regular consumption of Sinetrol (Journal of the Korean Society of Food Science and Nutrition; 45(4), 484-491(2016)): Sinetrol acts by facilitating lipolysis through a 2-step action on lipase activity and expression of the uncoupling protein (UCP) in mitochondria.
The effect of Sinetrol on human metabolism has been demonstrated by clinical studies on over 250 subjects on overweight and obese populations. Based on this scientific dossier Sinetrol is now granted by the MFDS (formerly KFDA) as an approved weight management ingredient:
◼ Rebalance of body composition: reduction of the excess of fat mass & increase of lean mass
◼ Reduction of abdominal fat, waist line, hip line
◼ Increased body tone and lean-to-fat mass ratio
◼ Increased resting energy expenditure (+181kcal/day) through beigeing benefits
Download the science pack to access the full publications
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> Latest news
> Sinetrol - New data
> MFDS releases approval on Sinetrol
> Complete the fruit & veggie daily intake to reach the 5-a-day
> Satiety peptides to innovate in appetite reduction supplements
> FIIT-NS - Metabolic Healthy Aging
> NEW GRADE OF OXXYNEA
> INTRODUCING DNF-10: Satiety peptides for weight management
> SINETROL PREVENTS THE WEIGHT-LOSS REBOUND EFFECT
> SINETROL ACTIVE LIVING
> FIIT-NS - VITALITY ISSUE
> OXXYNEA® - 22 FRUIT & VEGETABLES ANTIOXIDANT BENEFITS
> SINETROL® - NEW OUTCOMES
> PerLoad® & TensLess® - Publication of clinical studies
> International Life Sciences Awards 2017 - Fiit-ns®
> MANGOSELECT® - Joint Health Support
> SINETROL® - WEIGHT LOSS FACTS
> FIIT-NS® - New clinical study
> SINETROL® - New clinical study
> HOLISFIIT® - Publication of clinical results
> Sports Nutrition Webinar
> SPORTS NUTRITION – Acute benefits
> SINETROL® - White paper - Mechanism of action
> OXXYNEA® - Concentrate of 22 fruit and vegetables
> HOLISFIIT® - Target zen sports enthusiasts
> Fytexia enters in Sports Nutrition with a new range of ingredients
> OXXYNEA® - Mediterranean polyphenols
> Sales office opening in Asia-Pacific
> SINETROL® & FIIT-NS®: new studies results
> SINETROL® Xpur - new scientific results
> Joint Health: upgrade your formula with MANGOSELECT®
> CLINICALLY PROVEN INGREDIENTS BY FYTEXIA
> SINETROL® now available in stick-packs for innovation opportunities
> Fytexia takes new step in US extension by joining AHPA
> Fytexia ranks second at French national awards for international sales performance
> SINETROL® - Weight Management
> OXXYNEA Dtx - New ingredient
> FIIT-NS® – Metabolic Anti-Aging
Fat
Shredding
Technology™*
Sinetrol® is a patented weight management ingredient*, formulated from natural Mediterranean citrus. Sweet orange, blood orange and grapefruit extracts were selected to create a synergy of bioactive polyphenols targeting body composition benefits. The activity of Sinetrol® is enhanced with natural caffeine from guarana.
Sinetrol® helps stimulate lipolysis* through the inhibition of phosphodiesterase 4 (PDE-4), which leads to the breakdown of triglycerides stored in fat cells (adipocytes) and the release of free fatty acids (FFAs) and glycerol. In addition, polyphenols present in Sinetrol® have been reported to help induce the expression of fatty acid oxidation genes, which coax the metabolism toward the use of FFAs to produce additional energy. To determine the weight-loss benefits of Sinetrol®, a prospective placebo-controlled clinical study was conducted in 20 subjects. After 3 months, the Sinetrol group lost an average of 5.6kg and 22% of body fat compared to the placebo group.
Three clinical studies were conducted to investigate the benefits of Sinetrol® on body composition. With results from more than 190 subjects, this natural fat shredder is a proven safe solution for helping to reach a healthier lean-to-fat mass ratio.
The second clinical study was performed with 95 overweight subjects over 3 months who consumed a normal diet and limited physical activity to 30 mins/week (Dallas C. et al. Phytother. Res. 2014). Sinetrol® helped to enhance body composition:
The third clinical study, conducted on 77 overweight and obese subjects, confirms the benefits of Sinetrol® over 4 months:
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
** Before participating in any diet or exercise program, please consult your physician.
Mediterranean polyphenol
concentrate*
Awareness around the benefits of fruit and vegetable consumption is rising but the minimum daily intake of 400g recommended by the World Health Organization is struggling to be reached. Oxxynea® has been developed to fill the nutritional gap between the diet and the needs of consumers in terms of natural antioxidant polyphenols: formulated from grape, olive, pomegranate, green tea, grapefruit, bilberry and orange extracts, Oxxynea® brings a representative fingerprint of bioactive polyphenols.
450 mg of Oxxynea® provides the same antioxidant capacity as in 5 servings of fruit and vegetables. The equivalence has been built on the reference of the most consumed fruit and vegetables in France: tomato, apple, banana, orange and carrot. All sub-families of phenolic compounds are represented within Oxxynea® by four dominant families: flavan-3-ols, secoiridoids, ellagitannins and flavanones.
A double blind, randomized, placebo-controlled, cross-over clinical study has been conducted, demonstrating the bioavailability of the bioactive polyphenols of Oxxynea®. A model of meal-induced oxidative imbalance has been set up to evaluate the preventive effect of Oxxynea®:
Protection against oxidative stress:
Improved antioxidant capacity:
Oxxynea® at a daily dose of 450 mg, to be divided into 90 mg portions, each equalling 1 serving of fruit and vegetables.
> Available with organic extracts: Oxxynea O at 450 mg equalling 1 serving of fruit and vegetables
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Metabolic
anti-aging*
During the metabolic aging process, chronic low-grade metabolic disturbances are correlated with unbalanced oxidative stress that may gradually deteriorate lifestyle and condition of fitness. Fiit-ns® is a proprietary combination of extracts from grapefruit, grape, guarana, green tea, and black carrot, selected for their powerful antioxidant properties and for their ability to equilibrate various metabolic functions.
Polyphenols are natural bioactive compounds recognized to help the body with metabolic processes due to their antioxidant potency.
Thanks to its content of polyphenols, Fiit-ns® delivers benefits from a synergistic formulation to improve quality of life (QOL) by rejuvenating metabolic functions* and thereby limiting metabolic aging processes. Fiit-ns® is also enhanced with vitamin B3, which works synergistically to balance the energetic metabolism.
Two clinical studies demonstrate the benefits of Fiit-ns® on a total of 87 subjects:
The studies demonstrate that Fiit-ns® improves levels of metabolic markers, leading to a healthier lifestyle and a significant improvement of Quality of Life (QOL)*:
Fiit-ns® is proven to generate a virtuous cycle leading to a healthier lifestyle and greater QOL based on the rejuvenation of metabolic markers.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
** Before participating in any diet or exercise program, please consult your physician.
Joint health
support*
Slight muscle and connective tissue discomforts caused by strenuous activities affect millions of people worldwide. Mangosteen is a tropical fruit containing xanthones - specific polyphenols recognized in the international scientific literature for their antioxidant potency. Mangoselect® is characterized by its proprietary composition, including a- and g-mangostin, and is designed to help maintain joint health and comfort*.
Scientific reviews report that mangostins limit both the production and activity of the inflammatory enzyme cyclooxygenase-2 (COX-2) that controls the activation of the pro-inflammatory and pro-oxidant transcription factor NF-kB through direct stimulation of the peroxisome proliferator-activated receptor family (PPARs). Besides regulating the production of PPARs, a- and g-mangostins are also reported to limit the production of reactive oxygen species (ROS), cytokines, and inflammatory enzymes, while they may contribute to a safe and significant relief of pain in only few days.
Demonstrated efficacy*
Xanthones in Mangoselect® have been shown to alleviate joint discomfort in both elderly subjects and athletes:
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Satiety Peptides*
DNF-10 is an ingredient promoting weight management as proven with 4 clinical studies. This food-based ingredient is obtained from a screening of small molecular weight peptides (<10 kDa) after proteolysis of Saccharomyces cerevisiae.
DNF-10 addresses weight management through a regulation of the mediators of satiety. The peptides from DNF-10 lower the hypothalamic expression of neuropeptide Y and downregulate ghrelin, the inner hunger-promoter. Over the long term, DNF-10 is proven to also modulate the secretion of leptin, a satiety hormone secreted by the fat cells.
Four clinical studies were conducted to investigate the benefits of DNF-10 on weight loss, on more than 130 subjects:
The 4 studies are published and available upon request.
Water-soluble and heat-resistant, DNF-10 is recommended at a dosage of from 500 mg/day for the formulation of dietary supplements and functional foods.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
** Before participating in any diet or exercise program, please consult your physician.
Heavier
Performance*
The proprietary composition of PerfLoad® supplies bioactives selected for their specific action on metabolic functions to improve performance results: enhanced total anaerobic work capacity and higher peak power at same fatigue level. PerfLoad® is formulated from grapes, pomegranates and green tea. The benefits of resveratrol and flavonoids are enhanced with natural caffeine from green tea.
PerfLoad® specifically addresses the needs of athletes for explosive power during high-intensity exercise. Ensuring the needs of the body are met and that inner protection is optimized guarantees a healthy approach to maximize workout capacity. Managing key biological parameters such as blood pressure during and after workout, the natural ingredient offset the metabolic acceleration induced by sport practice. Fytexia solution for performance helps spare antioxidant reserves and replenish resources after a workout. PerfLoad® is scientifically formulated to arm the body to reach heavier peak levels of performance.
Fytexia collaborated with the Research Center of High Performance Sport (University of Murcia, Spain) to experiment the effects of Perfload on human metabolism.
In less than an hour after PerfLoad® intake, supplemented individuals develop a significant increase in power during the exercise:
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
PerfLoad is acceptable for use in sports and is none of its component is banned by athletic body per review of the 2017 Banned Substance List of WADA.
Heightened
Endurance*
BurntoRun® was designed to address athlete’s needs of endurance by a better mobilization of inner resources and an improvement of the maximal aerobic capacity during exercise (VO2max). BurntoRun® is a combination of citrus extracts known for their lipolytic activity, potentiated by L-carnitine to utilize liberated fatty acids as a privileged source of energy to surpass current workout endurance.
An overall metabolic characteristic endurance is defined by the ability to utilize oxygen over long distances: VO2max, the maximal aerobic capacity. In tandem with oxygen, the body draws on reserves to provide the resources required for the exercise. Glycogen-linked energy is the first source of reserve followed by lipid oxidation. Pure stamina, which represents the most important potential, is the ability to burn fats in the presence of oxygen; the higher the VO2max, the better pure stamina, and the better endurance capacity. BurntoRun® embraces this concept to provide inner fuel to go farther.
Fytexia worked in collaboration with the Research Center of High Performance Sport, (University of Murcia, Spain) to test BurntoRun® benefits on workout.
BurntoRun® provides significantly improved endurance capacities:
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
BurntoRun is acceptable for use in sports and is none of its component is banned by athletic body per review of the 2017 Banned Substance List of WADA.
Faster
Recovery*
TensLess® combines the benefits of mangosteen, pomegranate, and elderberry fruit extracts to synergistically reduce soreness feeling and preserve from muscle damages induced by sport practice. TensLess® offers a natural means of supporting the essential tenets of recovery from exercise: replenish, protect, and strengthen.
The recovery phase, corresponding to the interval of time required for full body repair from damage caused by sport sessions, constitutes an improvable adjustment variable to regain performance capacities. Research programs by Fytexia have shown that the mechanisms attending the use of TensLess® help to prevent and reduce muscle soreness and associated pain: myoglobin and creatinine, validated acute and mid-term biomarkers of muscle damage, are significantly decreased with TensLess® supplementation allowing athletes and fitness enthusiasts to resume training faster.
Fytexia explores the benefits of TensLess® on recovery in collaboration with the Research Center of High Performance Sport (University of Murcia, Spain).
TensLess® significantly protected the subjects from increased muscle damage*.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
TensLess is acceptable for use in sports and is none of its component is banned by athletic body per review of the 2018 Banned Substance List of WADA.
Weight management
for active lifestyles*
Sinetrol® Active living is a clinically proven ingredient for weight management, dedicated to active people to help boost the benefits of the physical activities they perform. Sinetrol Active Living combines extracts from orange, grapefruit & guarana with L-carnitine.
Sinetrol helps stimulate physiological lipolysis through the inhibition of phosphodiesterase, which leads to the breakdown of triglycerides into free fatty acids (FFAs) and glycerol. Also, during physical activity and mainly after glycogen depletion, lipolysis is the catabolic process maintaining energy requirements by drawing on adipocytes, which contributes to increased levels of FFAs. Sinetrol Active Living is formulated from citrus and guarana bioactives with L-carnitine, the fatty acid transporter involved during lipid oxidation for the production of energy within active muscle. Sinetrol Active Living operates at 2 levels: in the intensification of physiological adipose lipolysis and in the efficiency of fat transport – a metabolic pathway at the foundation of everyday aerobic-based exercise.
Two clinical studies (double-blind, randomized and placebo-controlled) support the benefits of Sinetrol Active Living.
Clinical study #1: 77 subjects (overweight and obese) during 16 weeks with a normal diet. This study confirmed the body-weight-loss benefits of the supplement:
Clinical study #2: 21 recreationally active subjects exercising 3 times a week:
Recommended dosage: 1.3 g/day
Applications: Food supplements
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
** Before participating in any diet or exercise program, please consult your physician.
This website is intended to provide information about Fytexia’s ingredients, used in various dietary supplement products around the world. It is intended to provide information to food supplement professionals and is not designed for general public. As Fytexia’s ingredients are being marketed in a large number of countries, it is the responsibility of each of our customers to ensure that the use of the ingredient and any claim made in the labeling or advertising of the ingredient is in compliance with the applicable rules and regulations.
