Body composition
& metabolism.
Characterization of the active compounds
Active Compounds
Primary active compounds:
Naringin
Hesperidin
Both expressed as flavanones > 40%
Secondary active compounds:
Other flavanones, caffeine
BOTANICAL SOURCES
Science supporting Sinetrol®
More than 10 years of research have been conducted to support the mechanism of action and clinical benefits of Sinetrol® on body composition.
Sinetrol® is a botanical ingredient studied in over 300 subjects and its benefits have been demonstrated using gold-standard methodology during interventional studies with follow-up.
Mechanism of action
Adipose tissue: regulation of fat stores through lipolysis
White adipose tissue (WAT) plays a critical role in whole body energy homeostasis. It stores excess energy in the form of triglycerides and releases fatty acids via lipolysis. The ratio between WAT and brown adipose tissue (BAT) regulates the level of energy expenditure, which is unbalanced in overweight and obese people.
Beiging of adipose tissue confers beneficial effects, increase the energy expenditure at the cellular level.
Sinetrol® works at the adipocyte level
1/ Sinetrol® enhances physiological lipolysis through PDE-inhibition.
2/ Sinetrol® intensifies FFA metabolization through promotion of the expression of mitochondrial uncoupling proteins (UCPs).
Increase in cAMP level induced by Sinetrol® promotes higher expression of UCPs as in beige adipose tissue.
- Increased energy expenditure from excess of FFAs released during lipolysis.
- Sinetrol® increases resting energy expenditure in supplemented volunters – Adipose beiging benefits
Pivotal clinical studies
Murcia, Spain
Clinical facility, UCAM
Seoul, Republic of Korea
Kangbuk Samsung Hospital
2017
20 weeks (16+4)
2019
12 weeks
77 subjects
Caucasian population
BMI: 25-40 kg/m2
Age: 29-52 years old
86 subjects
Asian population
BMI: 24-30 kg/m2
Age: 25-62 years old
Body composition
DXA scan
Recommended individualized
normo-caloric diet
(Harris and Benedict)
Body composition
DXA scan
Recommended
hypo-caloric diet
(-500 kcal hypocaloric diet)
CAPSULES
2 x 450 mg/day
TABLETS
1 x 900 mg/day
Primary outcome: body fat mass reduction
Body composition is rebalanced: lean-to-fat mass ratio significantly improves with Sinetrol®.
65% of the total fat loss was from the trunk area: Index of Central Obesity decreases significantly.
Waist & hip lines significantly decrease.
Long-lasting benefits
- Subjects continue to lose body weight.
- Subjects continue to reduce body fat mass.
- Proven mechanism of action: adipose beiging benefits
- Increase in resting energy expenditure
- Rebalanced body composition: significant reduction of body fat mass without lean mass loss
- Significant result on body weight, waist and hip lines
- Long-lasting benefits: Subjects continue to experience adipose beiging benefits
Applications
- Naringin
- Hesperidin
- Naringin
- Hesperidin
-
Flavanones (HPLC, 280 nm) > 40%
- Naringin
- Hesperidin
-
Caffeine 3.3-4%
An international reach
AUSTRALIA – BRAZIL – CANADA – CHINA – CZECH REPUBLIC – ENGLAND – FINLAND – FRANCE – GERMANY – HUNGARY – INDIA – INDONESIA – ITALIA – JAPON – LEBANON – MALAYSIA – MEXICO – POLAND – SAN MARINO – SERBIA – SOUTH AFRICA – SPAIN – SWITZERLAND – TAÏWAN – THAÏLAND – USA – VIETNAM
