Nutrient
supplementation.
Prebiotic fiber
Dietary fiber is the edible parts of plants or carbohydrates that are resistant to digestion and absorption in the human small intestine, with complete or partial fermentation in the large intestine. 20 to 30 g a day are recommended by the health authorities, in forms of food but this recommendation remains a hard-to-reach target.
Prebiotics are types of soluble fibers that serve as substrate for targeted beneficial bacteria of our microbiome.
Characterization of the active compounds
Rosiom® is a native chitin-glucan biopolymer from the cell wall of the mycelium of Aspergillus niger. Rosiom® combines in a 3D-structure, the nutritional benefits of β-glucan and chitin prebiotics, to modulate the gut microbiota and the production of postbiotics.
ACTIVE COMPOUNDS
Chitin: 30-60%
Glucan: 40-70%
Formulation
Recommended daily dosage: 4.5 g
15-year research program on Rosiom®
Rosiom® has been approved as Novel Food in Europe and has a self-affirmed GRAS status in the USA.
Rosiom®: targeted prebiotic effect for probiotic benefits
CLINICAL TRIAL 1
POPULATION
15 healthy men & women
Age: 21 ± 1 years old
LENGTH
21-day supplementation
INTAKES
4.5 g /day of Rosiom®
Fiber-controlled diet
Rosiom® modulates selectively the activity and composition of gut microbiota with a specific selection of positive bacteria (Roseburia spp), butyrate- and vaccenic acid-producer.
- Key role in the digestion of complex sugars
- Part of commensal bacteria producing short-chain fatty acids
- Sufficient presence of Roseburia is characteristic of a healthy gut & modification in abundance may affect various metabolic pathways
Rosiom®: postbiotic activity through short- & long-chain fatty acids (SCFA & LCFA)
IMMUNE HEALTH SUPPORT
WOMEN
CARDIOVASCULAR HEALTH
Rosiom® - Immune health support
EX-VIVO STUDY
Ex vivo approach on a human-like model of gut immune system axis: Caco-2 (epithelial cell line) / THP1 (macrophage cell line) co-culture.
Evaluation of the barrier function
The increase in the SCFA production is proven to reinforce epithelial thigh junctions:
Rosiom® improves the physical barrier first-line of immune defense.
Evaluation of the barrier function
The increased release of postbiotics modulates the inflammatory response:
- Pro- and anti-inflammation markers are rebalanced
- The inflammatory sentinel CXCL-10 significantly decreases
Rosiom® reinforces the second and third steps of the innate immune response.
Rosiom® – Cardiovascular health support
CLINICAL TRIAL
Double-blind, randomized, placebo-controlled
Multicenter study
POPULATION
37 healthy women
Age: 52 ± 12 years old
LCL-c normal to borderline
LENGTH
6-week supplementation
INTAKES
4.5 g /day of Rosiom®
Improvement of cholesterol homeostasis
PRE-CLINICAL STUDY
Golden Syrian hamster
Food-induced early atherosclerosis – Fatty streaks
12 weeks
Prevention of aortic fatty streaks
KEY OUTCOMES
- Patented ingredient
- Modulates selectively gut microbiota with a specific selection of Roseburia spp, butyrate- and vaccenic acid-producer
- Supports immune homeostasis
- Improves women cardiovascular health
- EU Novel Food Approval
- Self-affirmed GRAS
Applications
Chitin: 30-60%
Glucan: 40-70%
Food, functional food, dietary supplements
Patented ingredient, vegetarian, no allergen, non-GMO, halal, kosher, gluten-free
References
1 – PMID: 32893709
2 – PMID: 19222573
3 – PMID: 17209019
4 – PMID: 25722654
5 – PMID: 30915065
6 – PMID: 24390544
7 – PMID: 30939754
8 – PMID: 32893709
9 – PMID: 19154104
