Polyphenol concentrate as in 5-a-day

Nutrient
supplementation.

5 fruit and vegetables a day for NCDs prevention

A low consumption of fruit and vegetables is associated with a higher risk of developing non-communicable diseases (NCDs)¹. According to the World Health Organization (WHO), up to 3.9 million people could be saved each year if fruit and vegetable intake was increased².

Based on this evidence, the WHO issued recommendations for a 5-a-day minimum varied intake of fruit and vegetables – 400 g daily (5 servings of 80 g each).

Phenolic compounds as in 5 servings of fruit and vegetables

The worldwide consumption of fruit and vegetables is lower than recommendations.

Oxxynea® has been developed to fill the nutritional gap with our actual food intake by serving a large spectrum of polyphenols to mimic beneficial effects of a diverse diet and provide the same biological benefits as a regular and varied intake of fruit and vegetables.

Characterization of the active compounds

DIVERSITY OF BIOACTIVES

Oxxynea® provides a diversity of bioactives with more than 125 polyphenols from 5 main families of compounds: flavan-3-ols, flavanones, ellagitanins, secoiridoids, and anthocyanins.

SELECT BOTANICAL EXTRACTS

Oxxynea® is formulated from a carefully selected variety of botanicals: grape, olive, pomegranate, green tea, grapefruit, bilberry and orange extracts.

Green olive extract
Grape extract
Pomegranate extract
Green tea extract
Grapefruit extract
Bilberry extract
Citrus hesperidin

Olea europaea L.
Vitis vinifera L.
Punica granatum L.
Camellia sinensis (L.) Kuntze
Citrus paradisi Macfad
Vaccinum myrtillus L.
Citrus sinensis (L.) Osbeck

In a unique daily intake of 450mg, Oxxynea® delivers a similar quantity of polyphenols to 5 servings of the most consumed fruit and vegetables as measured with the Folin-Ciocalteu reagent. Oxxynea® has a higher antioxidant capacity than 5 servings of fruit and vegetables when measured ex vivo by the KRL test.

NUTRITIONAL CONTENT IN POLYPHENOLS

Folin Ciocalteu

230 mg gallic acid eq.

To compare with:
5 average servings of fruit & vegetables: 228 mg gallic acid eq.

ANTIOXIDANT CAPACITY

KRL TEST, ex vivo

295 mg gallic acid eq.

To compare with:
5 average servings of fruit & vegetables: 252 mg gallic acid eq.

FORMULATION

Recommended daily dose: 450 mg of Oxxynea® equivalent to 5 servings of fruit & vegetables.

1 serving
2 servings
3 servings
4 servings
5 servings

90mg/day
180mg/day
270mg/day
360mg/day
450mg/day

Science supporting Oxxynea®

A clinical study⁴ double-blind randomized, placebo-controlled, was conducted on healthy subjects in a cross-over* design to evaluate:

the bioavailability & kinetic of the active compounds
the acute benefits of Oxxynea® on the protection of the metabolism

*In cross-over studies, the participants will be switched throughout to all the treatment groups (both formulations and placebo) after a washout period.

Pharmacokinetic of the 24-hour release of Oxxynea® metabolites in the bloodstream

The pharmacokinetic of the release of the metabolites from Oxxynea® in the bloodstream allows confirming the bioavailability of the polyphenols from the different families engaged in the formula, as more than 40 different metabolites have been identified in the bloodstream.

Urinary excretion of Oxxynea® metabolites

Biological homeostasis benefits

Malondialdehyde: accurate biomarker of lipid peroxidation.
An increase in reactive oxygen species induced by high-fat/carbs meal causes overproduction of MDA in placebo.
Oxxynea® supplementation had a protective effect by limiting the MDA production.

Physiological homeostasis benefits

Mean Arterial Pressure: perfusion pressure experienced by organs and tissues.
Inverse causal relationship between

Oxxynea® circulating phenolic metabolites and 24-hour MAP variation.

Redox homeostasis benefits

Supplemented volunteers spared their antioxidant defenses, whether endogenous or exogenous, causing a sustained both biological and physiological homeostasis.

A daily intake from 90 to 450 mg/day provides the equivalent of polyphenols as in 1 to 5 servings of fruit & vegetables

Pharmacokinetic of absorption confirms a whole day release due to the diversity of bioactive polyphenols

Clinically proven to protect the metabolism

KEY OUTCOMES

Food-based ingredient
Rich diversity of bioactive polyphenols from various botanical sources
Same polyphenol content as in 5 servings of fresh fruit and vegetables
Same antioxidative protection as phenolic compounds from 5 servings of fresh fruit and vegetables
Helps maintaining biological and physiological homeostasis as in 5 servings of fresh fruit and vegetables for non-communicable disease prevention

Applications

Commercial name

Oxxynea® 5-a-day

COMPOSITION

Grape, olive, pomegranate, green tea, grapefruit, bilberry, orange extracts

ACTIVE COMPOUNDS

Total polyphenols (eq. gallic acid) ≥ 51%
KRL-Reseda (eq. gallic acid) ≥ 850 μmol/g

RECOMMENDED DOSAGE

450 mg/day

APPLICATIONS

Dietary supplements, functional foods & beverages

OTHERS

GMO-free, gluten-free, suitable for vegans

References
1 – Leenders et al.; Eur. J. Epidemiol.; 2015, 29(9)
2 – WHO; Increasing fruit and vegetable consumption to reduce the risk of non-communicable diseases; 2019
3 – Kantar world panel
4 – Romain et al.; Nutrients; 2022, 14, 49 13

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.