Polyphenol concentrate as in 5-a-day
5 fruit and vegetables a day for NCDs prevention
A low consumption of fruit and vegetables is associated with a higher risk of developing non-communicable diseases (NCDs)1. According to the World Health Organization (WHO), up to 3.9 million people could be saved each year if fruit and vegetable intake was increased2.
Based on this evidence, the WHO issued recommendations for a 5-a-day minimum varied intake of fruit and vegetables – 400 g daily (5 servings of 80 g each).
Phenolic compounds as in 5 servings of fruit and vegetables
Characterization of the active compounds
DIVERSITY OF BIOACTIVES
Oxxynea® provides a diversity of bioactives with more than 125 polyphenols from 5 main families of compounds: flavan-3-ols, flavanones, ellagitanins, secoiridoids, and anthocyanins.
SELECT BOTANICAL EXTRACTS
Oxxynea® is formulated from a carefully selected variety of botanicals: grape, olive, pomegranate, green tea, grapefruit, bilberry and orange extracts.
Green olive extract
Green tea extract
Olea europaea L.
Vitis vinifera L.
Punica granatum L.
Camellia sinensis (L.) Kuntze
Citrus paradisi Macfad
Vaccinum myrtillus L.
Citrus sinensis (L.) Osbeck
In a unique daily intake of 450mg, Oxxynea® delivers a similar quantity of polyphenols to 5 servings of the most consumed fruit and vegetables as measured with the Folin-Ciocalteu reagent. Oxxynea® has a higher antioxidant capacity than 5 servings of fruit and vegetables when measured ex vivo by the KRL test.
NUTRITIONAL CONTENT IN POLYPHENOLS
230 mg gallic acid eq.
To compare with:
5 average servings of fruit & vegetables: 228 mg gallic acid eq.
KRL TEST, ex vivo
295 mg gallic acid eq.
To compare with:
5 average servings of fruit & vegetables: 252 mg gallic acid eq.
Recommended daily dose: 450 mg of Oxxynea® equivalent to 5 servings of fruit & vegetables.
Science supporting Oxxynea®
A clinical study4 double-blind randomized, placebo-controlled, was conducted on healthy subjects in a cross-over* design to evaluate:
- the bioavailability & kinetic of the active compounds
- the acute benefits of Oxxynea® on the protection of the metabolism
*In cross-over studies, the participants will be switched throughout to all the treatment groups (both formulations and placebo) after a washout period.
Pharmacokinetic of the 24-hour release of Oxxynea® metabolites in the bloodstream
Urinary excretion of Oxxynea® metabolites
Biological homeostasis benefits
Malondialdehyde: accurate biomarker of lipid peroxidation.
An increase in reactive oxygen species induced by high-fat/carbs meal causes overproduction of MDA in placebo.
Oxxynea® supplementation had a protective effect by limiting the MDA production.
Physiological homeostasis benefits
Mean Arterial Pressure: perfusion pressure experienced by organs and tissues.
Inverse causal relationship between
Oxxynea® circulating phenolic metabolites and 24-hour MAP variation.
Redox homeostasis benefits
Supplemented volunteers spared their antioxidant defenses, whether endogenous or exogenous, causing a sustained both biological and physiological homeostasis.
A daily intake from 90 to 450 mg/day provides the equivalent of polyphenols as in 1 to 5 servings of fruit & vegetables
Pharmacokinetic of absorption confirms a whole day release due to the diversity of bioactive polyphenols
- Food-based ingredient
- Rich diversity of bioactive polyphenols from various botanical sources
- Same polyphenol content as in 5 servings of fresh fruit and vegetables
- Same antioxidative protection as phenolic compounds from 5 servings of fresh fruit and vegetables
- Helps maintaining biological and physiological homeostasis as in 5 servings of fresh fruit and vegetables for non-communicable disease prevention
Total polyphenols (eq. gallic acid) ≥ 51%
KRL-Reseda (eq. gallic acid) ≥ 850 μmol/g
1 – Leenders et al.; Eur. J. Epidemiol.; 2015, 29(9)
2 – WHO; Increasing fruit and vegetable consumption to reduce the risk of non-communicable diseases; 2019
3 – Kantar world panel
4 – Romain et al.; Nutrients; 2022, 14, 49 13