Nutrient
supplementation.
The power of human milk oligosacharides
Human milk oligosaccharides (HMOs) are complex sugars that are available in human milk. They are the 3rd largest solid component in breast milk after fat and lactose.
More than 150 different oligosaccharides have been identified in human milk and they have an overall prebiotic effect. This means that they pass undigested into the lower part of the gastrointestinal tract where they promote the growth of beneficial microorganisms, such as Bifidobacteria and Lactobacilli.
HMOs are responsible for directly supporting the immune system by:
HMOs: galactooligosaccharides are efficient prebiotics
- GOS consists of 3-10 molecules of galactose and glucose.
- These non-digestible prebiotics (non-digestible short-chain soluble fibers) have a prolonged beneficial effect in the large intestine and are effective at a low dose.
- GOS are resistant to temperature, gastric acids and to hydrolysis by human enzymes.
- They facilitates the growth of desirable intestinal microflora and can be selectively utilized by beneficial bacteria (Bifidobacteria and Lactobacilli).
Characterization of the active compounds
ACTIVE COMPOUNDS
Galactooligosaccharides
GOS > 70%
Formulation
Proven effective from 2000 mg/day
Process of manufacturing of high purity GOS
Science supporting GOS 70
In vitro evaluation of prebiotic activity
The ability of GOS 70 to support the in vitro growth of selected strains of probiotic bacteria has been investigated.
- GOS 70 selectively promotes the growth of beneficial microbiotypic bacteria (Lactobacilli and Bifidobacteria).
- The dose-response efficacy of GOS 70 demonstrates a causal relationship.
The symbiotic function of GOS 70 is confirmed.
SD rats were orally fed GOS 70 and/or Bifidobacteria for 30 days. Count of Bifidobacteria in the feces of the rats were performed at the end of the trial to assess of the prebiotic efficacy of GOS 70.
A larger amount of bacteria and a longer growth period is observed in the GOS 70 and Bifidobacteria group than in the Bifidobacteria group.
Symbiotic function of GOS 70 is confirmed.
A broad spectrum of health benefits
HMOs give newborns multiple layers of protection
Protect against
pathogenic infections
Promote the
development of intestine
Stimulate the maturation
of the immune system
Help establish
the gut microbiota
When breastfeeding is unavailable, optimization of infant nutrition is a principal factor required to further support immune development in early life. Research indicates that commercially produced HMOs can mimic some of the health-promoting effects of the HMOs present in human milk.
HMOs rich in galactosyllactose, such as GOS 70, allow for the creation of formulas that are closer to the profile of natural human milk to provide bottle-fed babies with the benefits of these essential components of breast milk.
Applications
Dry forms of dietary supplements
Instant powder or orodispersibles
Ready to drink beverages
Meal substitutes, nutritional bars, confectionery
Syrup and organic grade available
GRAS, GMO-free, gluten-free
References
K.B. HONG et al.; Food Technol. Biotechnol.; 2016, 54 (2) 156–163 (2016)
K.B. HONG et al.; Asia Pac. J. Clin. Nutr.; 2017;26(4):613-618
K.B. HONG et al.: Int. J. Food Sci. Nutr.; 2015, 66:8, 923-930
K.B. HONG et al.; Korean J. Food Nutr.; 2015, Vol. 28 No. 6, 1026-1032
Y.S. Seo et al.; Curr. Top. Lactic Acid Bac. Probio.; 2016; 4(2):48-53
